5-bromoindole-2-carboxylic acid
5-bromoindole-2-carboxylic acid
CAS: 7254-19-5
Molecular Formula: C9H6BrNO2
5-bromoindole-2-carboxylic acid - Names and Identifiers
| Name | 5-bromoindole-2-carboxylic acid |
| Synonyms | AKOS JY2082545 5-Bromo-2-indolecarboxylic acid 5-bromoindole-2-carboxylic acid 5-BROMOINDOLE-2-CARBOXYLIC ACID 5-BROMO-2-INDOLECARBOXYLIC ACID 5-BroMo-1H-indol-2-carboxylic acid 5-BROMO-1H-INDOLE-2-CARBOXYLIC ACID 5-bromo-1H-indole-2-carboxylic acid 1H-INDOLE-2-CARBOXYLIC ACID, 5-BROMO- 5-bromoindole-2-carboxylicacid5-Bromoindole-2-carboxylicacid |
| CAS | 7254-19-5 |
| InChI | InChI=1/C9H6BrNO2/c10-6-1-2-7-5(3-6)4-8(11-7)9(12)13/h1-4,11H,(H,12,13) |
5-bromoindole-2-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C9H6BrNO2 |
| Molar Mass | 240.05 |
| Density | 1.838±0.06 g/cm3(Predicted) |
| Melting Point | 287-288 |
| Boling Point | 470.9±25.0 °C(Predicted) |
| Flash Point | 238.611°C |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Solid |
| Color | White to Light yellow to Light orange |
| pKa | 4.25±0.30(Predicted) |
| Storage Condition | -20°C |
| Refractive Index | 1.749 |
| MDL | MFCD00022705 |
5-bromoindole-2-carboxylic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29339980 |
| Hazard Class | IRRITANT |
5-bromoindole-2-carboxylic acid - Introduction
Acid is an organic compound with the chemical formula C9H6BrNO2.
The following are some properties and characteristics of acid:
Nature:
-Appearance: acid is a white to yellowish crystalline solid.
-Solubility: It is soluble in some organic solvents at room temperature, such as dimethyl sulfoxide and dimethylformamide.
Use:
-acid is a commonly used organic synthesis intermediate, commonly used in the synthesis of drugs, pesticides and dyes and other compounds.
Preparation Method:
-or acid can be prepared by the following steps:
1. Starting from indole, bromination reaction is carried out with bromine gas under alkaline conditions, and bromine is added to the C5 position on the indole ring to obtain 5-bromoindole.
2. then 5-bromo indole and cyanoacetate reaction, nucleophilic addition occurs, generating 5-bromo indole -2-carboxylic acid ethyl ester.
3. Finally, hydrolyze ethyl 5-bromoindole-2-carboxylate to obtain acid.
Safety Information:
-the safety information of acid is limited, but general laboratory safety procedures should be followed when handling and using.
-It may be irritating to the eyes, skin and respiratory tract, so wear appropriate personal protective equipment, such as safety glasses and gloves.
-The storage and handling of oxidizing chemicals should be carried out in accordance with local regulations.
The following are some properties and characteristics of acid:
Nature:
-Appearance: acid is a white to yellowish crystalline solid.
-Solubility: It is soluble in some organic solvents at room temperature, such as dimethyl sulfoxide and dimethylformamide.
Use:
-acid is a commonly used organic synthesis intermediate, commonly used in the synthesis of drugs, pesticides and dyes and other compounds.
Preparation Method:
-or acid can be prepared by the following steps:
1. Starting from indole, bromination reaction is carried out with bromine gas under alkaline conditions, and bromine is added to the C5 position on the indole ring to obtain 5-bromoindole.
2. then 5-bromo indole and cyanoacetate reaction, nucleophilic addition occurs, generating 5-bromo indole -2-carboxylic acid ethyl ester.
3. Finally, hydrolyze ethyl 5-bromoindole-2-carboxylate to obtain acid.
Safety Information:
-the safety information of acid is limited, but general laboratory safety procedures should be followed when handling and using.
-It may be irritating to the eyes, skin and respiratory tract, so wear appropriate personal protective equipment, such as safety glasses and gloves.
-The storage and handling of oxidizing chemicals should be carried out in accordance with local regulations.
Last Update：2024-04-09 21:00:56
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